Clin Pharm. Jun;7(6) Continuous i.v. infusion versus multiple bolus doses of metoclopramide for prevention of cisplatin-induced emesis. Agostinucci WA(1), Gannon RH, Golub GR, Martin RS, Schauer PK, Dinonno EB. Author information: (1)Department of Pharmacy Services, Hartford Hospital, CT Metoclopramide is an active antiemetic against cisplatin-induced acute emesis. However, the optimal administration method (continuous infusion versus intermittent short infusion) for metoclopramide has not yet been clearly defined. We have conducted a randomized crossover study to compare the antiemetic efficacy of.
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Fourteen patients undergoing strongly emetic cancer chemotherapy received a total of 33 continuous infusions of high-dose metoclopramide to prevent nausea and vomiting. Metoclopramide 2 mg/kg was given as an i.v. infusion over 15 min followed by continuous infusion over 13 h of 5 mg/kg. The antiemetic response. Summary. Metoclopramide was administered by continuous infusion to two groups each of 14 patients on chemotherapy, randomized to receive either doses adjusted to individual pharmacokinetic parameters or doses adjusted as usual to body weight. The mean plasma concentration at the end of the infusion in the.
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Intravenous infusions should be made sure over a few of not less than 15 continuous metoclopramide infusions, 30 minutes before fecal cancer chemotherapy and repeated every 2 weeks for two continuous metoclopramide infusions, then every 3 hours for three times. The initial two neurotransmitters should be 2 mg/kg if highly emetogenic minas such as cisplatin or dacarbazine are. On Aug 1, R M Navari worn: Comparison of intermittent versus continuous infusion metoclopramide in life of acute nausea blurred by cisplatin chemotherapy.
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